Introduction: The Science of Living Better for Longer
Longevity science has exploded in recent years. Researchers like Dr David Sinclair, Dr Peter Attia, and Dr Rhonda Patrick have brought the biology of ageing into the mainstream — and with it, a growing understanding of which supplements can genuinely support a longer, healthier life.
But with hundreds of supplements on the market, it can be hard to know where to start. In this guide, we've cut through the noise to bring you the most evidence-backed longevity supplements available today — all of which are available in Vitalitya's range.
What Causes Ageing?
Modern longevity science identifies several key hallmarks of ageing — biological processes that drive the decline we associate with getting older:
- Declining NAD+ levels — NAD+ is essential for cellular energy and DNA repair, and levels drop by up to 50% by our 50s
- Accumulation of senescent cells — "zombie cells" that no longer function but release inflammatory signals
- Mitochondrial dysfunction — the energy factories of our cells become less efficient with age
- Chronic inflammation — low-grade inflammation drives many age-related diseases
- Oxidative stress — free radical damage accumulates over time
- Loss of proteostasis — the body's ability to clear damaged proteins declines
The best longevity supplements target one or more of these hallmarks directly. Here's our evidence-based rundown.
The Best Longevity Supplements
1. NMN (Nicotinamide Mononucleotide) — The NAD+ Booster
NMN is arguably the most talked-about longevity supplement of the past decade. As a direct precursor to NAD+, it replenishes the cellular energy currency that declines with age — supporting DNA repair, mitochondrial function, and sirtuin activation.
Clinical trials have shown NMN improves muscle function, energy metabolism, and insulin sensitivity. It's the foundation of many longevity protocols.
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2. Resveratrol — The Sirtuin Activator
Resveratrol is a polyphenol found in red wine and grapes that activates sirtuins — the longevity proteins that regulate cellular health and ageing. It works synergistically with NMN, and the combination has been popularised by Dr David Sinclair as a core longevity stack.
Research shows Resveratrol supports cardiovascular health, reduces inflammation, and may protect against age-related cognitive decline.
3. Fisetin — The Senolytic
Fisetin is a flavonoid found in strawberries that has emerged as one of the most potent natural senolytics — compounds that clear senescent (zombie) cells from the body. A Mayo Clinic study found Fisetin to be the most potent senolytic of 10 flavonoids tested.
By clearing senescent cells, Fisetin helps reduce the chronic inflammation they cause — one of the primary drivers of age-related disease.
4. Quercetin — The Anti-Inflammatory Flavonoid
Quercetin is another powerful flavonoid with senolytic and anti-inflammatory properties. It's often stacked with Fisetin for enhanced senolytic effect, and has additional benefits for immune function, cardiovascular health, and gut health.
5. Spermidine — The Autophagy Activator
Spermidine is a naturally occurring polyamine that declines with age. It's one of the most exciting longevity compounds because it activates autophagy — the body's cellular recycling process that clears damaged proteins and organelles. Autophagy is essential for cellular renewal and is strongly associated with longevity.
6. Berberine — The Metabolic Regulator
Berberine activates AMPK — the body's metabolic master switch — with effects comparable to Metformin (one of the most studied longevity drugs). It supports healthy blood sugar, reduces inflammation, and improves metabolic health — all key factors in healthy ageing.
7. NAD+ — Direct Cellular Energy Support
While NMN is the most efficient way to raise NAD+ levels, direct NAD+ supplementation offers an additional route to supporting cellular energy, particularly for those looking for comprehensive NAD+ support.
8. PQQ — The Mitochondrial Booster
PQQ (Pyrroloquinoline Quinone) is a powerful antioxidant that supports mitochondrial biogenesis — the creation of new mitochondria. More and healthier mitochondria means more cellular energy and better protection against age-related decline. PQQ pairs exceptionally well with NMN.
9. Liposomal Glutathione — The Master Antioxidant
Glutathione is the body's most powerful antioxidant, protecting cells from oxidative damage. Levels decline significantly with age. Liposomal delivery ensures superior absorption compared to standard glutathione supplements.
10. TMG (Trimethylglycine) — The Methylation Supporter
TMG is an important addition to any NMN or NAD+ protocol. NMN supplementation can deplete methyl groups in the body, and TMG replenishes them — supporting healthy methylation, homocysteine balance, and cardiovascular health.
The Vitalitya Longevity Stack
For those looking to build a comprehensive longevity protocol, here's how our most popular supplements work together:
- Core NAD+ stack: NMN 500mg + Resveratrol 1000mg + TMG 1000mg (taken in the morning)
- Senolytic protocol: Fisetin 250mg + Quercetin 500mg (taken periodically, e.g. 2–3 days per month)
- Cellular health: PQQ 20mg + Liposomal Glutathione (daily)
- Metabolic support: Berberine 500mg (with meals)
- Autophagy: Spermidine 5mg (daily)
For an all-in-one option, our NMN+1200 combines NMN, Resveratrol, and Pterostilbene in a single capsule — a convenient starting point for a longevity protocol.
Lifestyle Factors That Amplify Supplement Benefits
Supplements work best alongside healthy lifestyle habits. The longevity researchers who take these supplements themselves also prioritise:
- Exercise — particularly resistance training and Zone 2 cardio
- Sleep — 7–9 hours of quality sleep is non-negotiable for cellular repair
- Diet — a whole-food diet rich in polyphenols, healthy fats, and lean protein
- Stress management — chronic stress accelerates ageing through cortisol and inflammation
- Time-restricted eating — intermittent fasting activates autophagy naturally
Final Thoughts
The science of longevity is advancing rapidly, and we now have more tools than ever to support healthy ageing at the cellular level. Whether you're just starting your longevity journey or looking to optimise an existing protocol, Vitalitya's range has everything you need.
As always, we recommend consulting with a healthcare professional before starting any new supplement regimen, particularly if you have existing health conditions or are taking medication.
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